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Rapid agers experience a faster rate of However, it is clear from studies in
functional deterioration relative to their identical twins – who share the same genes
chronological age. but not the same exact lifespans – that
My grandmother, who lived to be 83 but genes are not the only factor that influences
was bedridden and could not remember aging. In fact, genes probably account for
who I was for the last few years of her life, only 20% to 30% of biological age. This
was a rapid ager. My grandfather, on the suggests that other parameters can strongly
other hand, also lived until he was 83, but influence biological aging.
he was active, functional and even did my
homework with me until he passed away – Environmental and lifestyle effects
he was a healthy ager.
With the unprecedented growth of the
world’s aging population, I believe that
figuring out ways to measure biological age
and how to maintain or delay its advance is
critical not only for individual health, but
also for the social, political and economic
health of our society. Detecting rapid agers
early on presents an opportunity to delay,
change or even reverse the trajectory of
biological aging.
Genetics and biological age Social connectedness and physical activity are linked to
Biological aging is multifaceted. It arises well-being throughout life
from a complex mix of genetic traits and Researchers have found that
is influenced by factors like microbiome environmental and lifestyle factors heavily
composition, environment, lifestyle, stress, influence biological age, including social
diet and exercise. connectedness, sleeping habits, water
Genetics were once thought to have no consumption, exercise and diet.
influence on aging or longevity. However, Social connectedness is essential for
in the early 1990s, researchers reported well-being throughout life. But social
the first studies identifying genes that connections can be challenging to maintain
were able to extend the lifespan of a over time due to loss of family and friends,
small roundworm. Since then, multiple depression, chronic illness or other factors.
observations support the influence of Several studies have reported a strong link
genetics on aging. between social isolation and increased
For example, children of long-lived stress, morbidity and mortality.
parents and even those with long-lived Similarly, diet and exercise are strong
siblings tend to live longer. Researchers influencers of biological age. Blue zones
have also identified multiple genes that which are areas around the world where
influence longevity and play a role in people live long lives, attribute their
resilience and protection from stress. These successful aging to diet, exercise and social
include genes that repair DNA, protect cells connectedness. Mostly plant-based meals
from free radicals and regulate fat levels. and spurts of activity throughout the day
SENIORS TODAY | ISSUE #47 | MAY 2023 17
